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Synthesis 1994; 1994(12): 1463-1466
DOI: 10.1055/s-1994-25714
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Improved Synthesis of Chiral N-Protected Allylic Amines

Zhong-Yong Wei* , Edward E. Knaus
  • *Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, T6G 2N8, Canada
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Publication History

Publication Date:
25 April 2002 (online)

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The α-ester group of N-protected α-amino esters was reduced with diisobutylaluminum hydride to an intermediate aluminoxy acetal that on reaction with a Wittig reagent afforded the title chiral compounds in 48-78% chemical yields.