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Synthesis 1995; 1995(1): 97-100
DOI: 10.1055/s-1995-3848
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Benzyloxy(diisopropylamino)methylphosphine: A Powerful Reagent for the Synthesis of Methylphosphonopeptides

Jac C.H.M. Wijkmans, Wendelien Ottenheim, Esther Kuyl-Yeheskiely, Gijs A. van der Marel, Wim Bloemhoff, Jacques H. van Boom*
  • *Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands
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Publication Date:
31 December 2000 (online)

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The preparation of methylphosphonylated amino acids and peptides using O,O-bis(benzotriazol-1-yl) methylphosphonate and the favourable novel reagent benzyloxy(diisopropylamino)methylphosphine [benzyl (N,N-diisopropyl)methylphosphonamidite] is described.

Reagent 2 was used for the preparation of methylphosphonopeptide 1b.