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Synthesis 1995; 1995(2): 187-190
DOI: 10.1055/s-1995-3879
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Enantiodivergent Preparation of Optically Pure Tricyclic Cyclohexanoids via Lipase-Mediated Asymmetrization of a meso-Symmetric Starting Material

Minoru Moriya, Takashi Kamikubo, Kunio Ogasawara*
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-77, Japan
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Publication Date:
31 December 2000 (online)

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Two potentially useful, optically pure, tricyclohexanoids having 1,4-ethanohydronaphthalen-5-one system have been prepared in an enantiodivergent way from a single chiral tricyclic cyclohexanoid precursor obtained by lipase-mediated asymmetrization of a meso-symmetric starting material.

asymmetrization of meso-substrate - lipase-mediated asymmetrization - enantiodivergent synthesis - chiral cyclohexanoid synthon - chiral 1,4-ethanohydronaphthalene