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Synthesis 1995; 1995(2): 144-146
DOI: 10.1055/s-1995-3880
short paper
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Novel Approach to the Synthesis of Alkoxycarbonylmethyl- and Bis(alkoxycarbonylmethyl)phosphine Oxides Based on a Reformatsky-Type Reaction

Piotr Kiełbasiński* , Marian Mikołajczyk
  • *Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Organic Sulfur Compounds, Sienkiewicza 112, 90-363 Łodź, Poland
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Publication Date:
31 December 2000 (online)

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A new procedure for the preparation of alkoxycarbonylmethyl- and bis(alkoxycarbonylmethyl)phosphine oxides is described, which consists of a Reformatsky-type reaction between chlorophosphines or dichlorophosphines and alkyl bromoacetates in the presence of zinc, followed by oxidation.

alkoxycarbonylomethylphosphine oxides - bis-(alkoxy-carbonylmethyl)phosphine oxides - Reformatsky-type reaction