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Synthesis 1995; 1995(4): 427-430
DOI: 10.1055/s-1995-3919
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Studies on Aryl H-Phosphonates; Part 2: A General Method for the Preparation of Alkyl H-Phosphonate Monoesters

Annika Kers, Inger Kers, Jacek Stawiński1 , Michal Sobkowski, Adam Kraszewski2
  • 1Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden
  • 2Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, PL-61-704 Poznan, Poland
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Publication Date:
31 December 2000 (online)

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A simple and efficient synthetic method for the preparation of alkyl H-phosphonate monoesters has been developed. The method consists of transesterification of commercially available diphenyl H-phosphonate with an appropriate alcohol under mild conditions, followed by ammonolysis of the in situ formed dialkyl and alkyl phenyl H-phosphonates.

diphenyl H-phosphonate - transesterification - alkyl H-phosphonates