Download PDF
Synthesis 1995; 1995(5): 475-497
DOI: 10.1055/s-1995-3957
review
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

π Stacking Effects in Asymmetric Synthesis

Graham B. Jones* , Brant J. Chapman
  • *Department of Chemistry, Clemson University, Clemson, South Carolina, SC 29634-1905, USA, Fax +1(803)6566613; E-mail graham@clemson.edu
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The effects and benefits of π stacking in asymmetric synthesis is reviewed. Specifically, asymmetric induction achieved with chiral auxiliaries and chiral catalysts can be enhanced by π stacking effects, locking one confirmation of a reactant preferentially in a given transition state assembly. The evolution of such systems, their application in synthesis, together with related developments in the field of molecular recognition will be highlighted.

π stacking - asymmetric synthesis - enantioselective catalysts - chiral auxiliaries - molecular recognition