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Synthesis 1995; 1995(6): 635-637
DOI: 10.1055/s-1995-3975
short paper
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An Expedient Synthesis of Ethyl 4(5)-Alkyl(aryl)thioimidazole-5(4)-carboxylate

Jean C. Caille* , Stanislas Didierlaurent, Dominique Lefrançois, Marie H. Lelièvre, Christelle Sury, Jozsef Aszodi
  • *Centre de Recherche Roussel-Uclaf, F-93235 Romainville Cedex, France, Fax +33(41)427655
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Publication History

Publication Date:
31 December 2000 (online)

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Various ethyl 4-alkyl(aryl)thioimidazole-5-carboxylates have been synthesized by the reaction of ethyl valeramidocyanoacetate with a variety of alkyl(aryl) thiols in the presence of triethylamine and subsequent phosphorus pentachloride/4-dimethylaminopyridine (DMAP) mediated cyclization of the acyclic intermediates.

imidazole - thioalkyl(aryl) imidazole - cyclization - thiol addition - pharmaceutical intermediate