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Synthesis 1995; 1995(6): 707-712
DOI: 10.1055/s-1995-3977
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Copper(I) Iodide: A Catalyst for the Improved Synthesis of Aryl Propargyl Ethers

David Bell, Mark R. Davies, Graham R. Geen, Inderjit S. Mann*
  • *SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, England, Fax +44(1279)622348
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Publication Date:
31 December 2000 (online)

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Copper(I) iodide catalyses the reaction between phenols and dialkylpropargyl chlorides to give aryl 1,1-dialkylpropargyl ethers 5a-k and 7a-e in good yields and purity. These ethers are important as precursors to the 2H-1-benzopyrans 8a-l and 9a-e.

Copper(I) iodide catalysed synthesis of aryl 1,1-dialkylpropargyl ethers