Download PDF
Synthesis 1995; 1995(6): 683-686
DOI: 10.1055/s-1995-3980
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Epimerization-Free Amidation of Protected Peptide Acids

Csaba Somlai* , Gyula Szókán, Botond Penke
  • *Department of Medical Chemistry, Albert Szent-Györgyi Medical University, Dóm tér 8, H-6720 Szeged, Hungary, Fax +36(62)313833
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

An investigation was performed on the formation of amides and substituted amides of N-(9-fluorenylmethoxycarbonyl) di-, tri-, tetra-, penta- and hexapeptide acids with the crystalline ammonium, methylammonium, ethylammonium and benzylammonium salts of N-hydroxysuccinimide, and also on the rates of racemization in the amidation process. The precise stereochemical purities of the products were measured by conventional HPLC, using pre-column derivatization with Marfey’s reagent, and proved to be on average 98%.

amidation - chirality - optical purity - peptide - racemization

      >