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Synthesis 1995; 1995(7): 780-786
DOI: 10.1055/s-1995-3992
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Coccidiostatic Agents: Synthesis of some Analogs of (±)-Frenolicin B

Thierry Masquelin* , Urs Hengartner, Jacques Streith
  • *Pharma Research, F. Hoffmann-La Roche AG, CH-4002 Basel, Switzerland, Fax +41(61)6881075
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Publication History

Publication Date:
31 December 2000 (online)

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Starting from juglone derivative 5, a series of frenolicin B analogs 15 (R1 = R2 = Me), 19a (R1 = H, R2 = Ph), and 19b (R1 = Ph, R2 = H) were obtained via the key β-hydroxy ester intermediate 10 in a twelve step synthesis.

coccidiosis - frenolicin B - β-hydroxy-ester - pyronaphthoquinone - γ-lactonisation