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Synthesis 1995; 1995(7): 763-765
DOI: 10.1055/s-1995-4003
short paper
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A Simple Cyclization Route to Some 4-Substituted 3-Aminoisoquinolines

Hitomi Suzuki* , Hajime Abe
  • *Department of Chemistry, Faculty of Science, Kyoto University, Sakyo-ku, Kyoto, 606-01, Japan, Fax +81(75)7512085
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Publication Date:
31 December 2000 (online)

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3-Aminoisoquinolines with an electron-withdrawing substituent at the 4-position can be easily obtained by the room temperature reaction of o-iodobenzylamine and α-substituted acetonitriles in dimethyl sulfoxide in the presence of copper(I) bromide and a tertiary amine.

CuBr-catalyzed reaction of o-iodobenzylamine and α-substituted acetonitriles yields 4-substituted 3-aminoisoquinolines