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Synthesis 1995; 1995(7): 777-779
DOI: 10.1055/s-1995-4008
short paper
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Novel Synthetic Route to 1-Substituted Cytosines

Krzysztof Ciszweski, Lech Celewicz, Krzysztof Golankiewicz*
  • *Faculty of Chemistry, Adam Mickiewicz University, Grundwaldzka 6, PL-60-780 Poznań, Poland, Fax +48(61)658008
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Publication History

Publication Date:
31 December 2000 (online)

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1-Alkylcytosines, cytidine and 2’-deoxy-5-methylcytidine were synthesized in good yields from appropriate 1-alkyluracils, uridine or thymidine derivatives by hydrogenation of 6-substituted tetrazolo[1,5-c]pyrimidin-5(6H)-ones 2 over 10% palladium on charcoal in methanol. Compounds 2 were obtained by the reaction of 1-substituted uracils 1 with sodium azide and phosphorus oxychloride in acetonitrile.

preparation of 6-substituted tetrazolo[1,5-c]pyrimidin-5(6H)-ones - catalytic hydrogenation - 1-substituted cytosines