PDF herunterladen
Synthesis 1995; 1995(9): 1074-1076
DOI: 10.1055/s-1995-4050
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Convenient One-Pot Preparation of Disubstituted Phosphinic Acids Derived from Simple Amino Acids and Proline

Marianne Borloo, Xian-Yun Jiao, Halina Wójtowicz, Padinchare Rajan, Christophe Verbruggen, Koen Augustyns, Achiel Haemers*
  • *Department of Pharmaceutical Chemistry, University of Antwerp (UIA), Universiteitsplein, 1, B-2610 Antwerpen, Belgium
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

A facile method for the preparation of both 2-pyrrolidinyl-substituted phosphinic acids and 1-aminoalkylphosphinic acids is described. Reaction of 1-pyrroline trimer or N-tritylalkanamine with bis(trimethylsilyl)phosphonite, followed by silylation with N,O-bis(trimethylsilyl)acetamide gives an intermediate which is used in a Michael addition reaction or an Arbuzov reaction.

phosphinic acids - bis(trimethylsilyl) phosphonite - 1,4-Michael-type addition - Arbuzov reaction - α-aminoalkylphosphinic acid - 2-pyrrolidinylphosphinic acid