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Synthesis 1995; 1995(10): 1291-1294
DOI: 10.1055/s-1995-4090
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Lipase-Mediated Preparation of Optically Pure Four-Carbon Di- and Triols from a meso-Precursor

Osamu Yamada, Kunio Ogasawara*
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-77, Japan, Fax +81(22)2176845; E-mail c21799@cctu.cc.tohoku.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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An expedient route to optically pure four-carbon di- and triols, prepared from a meso-symmetric four-carbon precursor by employing lipase-mediated kinetic resolution as a key step.

lipase-mediated kinetic resolution - chiral four-carbon polyols - meso-symmetric substrate - chiral 3-butyne-1,2-diol - double elimination