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Synthesis 1995; 1995(10): 1205-1222
DOI: 10.1055/s-1995-4099
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Steric Promotion of Ring Formation

Peter G. Sammes* , David J. Weller1
  • *Molecular Probes Unit, Department of Chemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK
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Publication History

Publication Date:
31 December 2000 (online)

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Intramolecular cycloaddition reactions are of paramount importance in synthesis. Steric effects are extremely important in either helping or hindering such reactions and this paper reviews progress from initial observations at the turn of the century to present ideas on conformational control. Steric buttressing is an extremely simple method for encouraging difficult reactions. The effects of external factors are also briefly covered.

The use of steric buttressing and conformational control in cycloaddition reactions is described