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Synlett 1995; 1995(1): 108-110
DOI: 10.1055/s-1995-4846
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Thiocarbamates as Novel Backbone Analogs in Oligonucleotides

Adrian Waldner* , Alain De Mesmaeker
  • *Central Research Laboratories, CIBA-GEIGY Ltd., CH-4002 Basel, Switzerland
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Publication History

Publication Date:
31 December 2000 (online)

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The synthesis of a thymidine dimer containing a thiocarbamate moiety as internucleosidic linkage replacement is described. This new dimer was incorporated in oligodeoxyribonucleotides and the melting temperatures (Tm’s) of the DNA/RNA duplexes were determined.

Thiocarbamate - Oligonucleotides - Antisense - Backbone - Nucleic Acids