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Synlett 1995; 1995(2): 149-150
DOI: 10.1055/s-1995-4893
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A 1,3-Dipolar Cycloaddition Route to 3-Acyl-4-hydroxy-pyridin-2-ones and -pyran-2-ones

Raymond C. F. Jones* , Gurdip Bhalay, Paul A. Carter, Kathryn A. M. Duller, Simone I. E. Vulto
  • *Chemistry Department, Nottingham University, Nottingham NG7 2RD, U.K.
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Publication History

Publication Date:
31 December 2000 (online)

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The 1,3-dipolar cycloaddition of nitrile oxides to enamines formed from 5-benzyloxycarbonylamino-3-ketoesters affords 4-carboxyisoxazoles that are converted via isoxazolo[4,5-c]pyridin-4-ones into 3-acetyl-4-hydroxypyridin-2-ones.

pyridone - isoxazole - nitrile oxide - dipole - cycloaddition