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Synlett 1995; 1995(2): 165-166
DOI: 10.1055/s-1995-4898
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Mild Conversion of Aryl Halides to ArylTrifluoromethyl Ketones

Joseph W. Guiles*
  • *Sterling Winthrop Pharmaceuticals Research Division, 1250 S. Collegeville Rd., Collegeville, PA 19426-0900
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Publication History

Publication Date:
31 December 2000 (online)

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Aryltrialkyltins derived from aryl halides have been found to cross-couple with trifluoroacetic anhydride in the presence of a palladium(0) catalyst. This method provides a chemoselective alternative to existing processes that rely upon organolithium bases, or electrochemical apparatus for the generation of aryltrifluoromethyl ketones.

aryl stannanes - trifluoromethyl ketones - palladium catalyzed