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Synlett 1995; 1995(2): 157-158
DOI: 10.1055/s-1995-4904
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Synthesis of 3-Pyridylpropenoic Acid Esters via Heck Coupling of Substituted 3-Pyridyl Triflates

Tandy L. Draper, Thomas R. Bailey*
  • *Department of Medicinal Chemistry, Research Division, Sanofi Winthrop, Inc., 1250 South Collegeville Rd., Collegeville, PA 19460-0900, USA
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Publication Date:
31 December 2000 (online)

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From commercially available 3-hydroxypyridines, several 3-pyridinepropenoic ethyl esters were prepared in good yield via Heck coupling of ethyl acrylate and the pyridyl triflate. In general, LiCl accelerated the coupling, but was not required for all reactions.

Heck coupling - 3-Pyridyl triflates - 3-pyridylpropenoic acid esters - palladium