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Synlett 1995; 1995(5): 443-444
DOI: 10.1055/s-1995-5000
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Metallic Samarium and Iodine in Alcohol. Selective 1,4-Reduction of α,β-Unsaturated Carboxylic Acid Derivatives

Reiko Yanada* , Kiyoshi Bessho, Kazuo Yanada
  • *Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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Olefinic double bond of various α,β-unsaturated carboxylic acid derivatives (ester, amide, nitrile, carboxylic acid) is reduced with metallic samarium and iodine to the corresponding saturated products in high yields in alcohol at room temperature under argon.

α,β-unsaturated ester - amide - nitrile - carboxylic acid - metallic samarium - olefin - 1,4-reduction