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Synlett 1995; 1995(6): 647-649
DOI: 10.1055/s-1995-5015
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Efficient and Practical New Synthesis of 2-Oxazolines; 1,2-Bis- and 1,3-Bis(oxazolinyl)benzenes by [3+2] Cycloaddition Using Solvent-Free Conditions

Jean Michel Lerestif, Jean Pierre Bazureau* , Jack Hamelin
  • *Groupe de Recherches de Physico-Chimie Structurale 3 associé au CNRS, Campus de Beaulieu, F-35042 Rennes Cédex, France
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Publication History

Publication Date:
31 December 2000 (online)

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New 2-oxazolines, 1,2-bis- and 1,3-bis(oxazolinyl)benzenes were synthesized respectively from aliphatic, aromatic aldehydes, cinnamaldehyde, activated ketones, phthalic dicarboxaldehyde, isophthalaldehyde and imidate 1a derived from dimethyl aminomalonate by regioselective 1,3-dipolar cycloadditions using solvent-free conditions at 70°C.

[3+2] Cycloaddition - imidates - aldehydes - ketones - 2-oxazolines