Download PDF
Synlett 1995; 1995(6): 599-602
DOI: 10.1055/s-1995-5025
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Biocatalysis in Organic Synthesis. 6. First Use of an Acylase as Catalyst in the Irreversible Transacylation of Alcohols and Amines: Application to Selective Transformations1

Bernardo Herradón* , Serafín Valverde
  • *Instituto de Química Orgánica General, C.S.I.C., c/ Juan de la Cierva 3, 28006 Madrid, Spain
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The acylase from Aspergillus species catalyzes the acylation of alcohols and amines using vinyl acetate as irreversible acyl-transfer reagent. This is the first time that this enzyme has been employed to catalyze this kind of reaction. The method has been used in chemo-, regio-, and enantioselective transformations.

Alcohol - amine - kinetic resolution - acylase - selective transformations