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Synlett 1995; 1995(6): 613-614
DOI: 10.1055/s-1995-5030
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A Convenient Synthesis of 1-(S)-[1’-(S)-(t-Butyloxycarbonylamino)-2’-phenylethyl]oxirane, a Versatile Intermediate for the Preparation of Hydroxyethylamine Based HIV Protease Inhibitors

Brian E. Green, Xiaoqi Chen, Daniel W. Norbeck, Dale J. Kempf*
  • *D-47D, AP9A, Pharmaceutical Products Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, Fax (708) 938-6603; Internet kempf.dale@igate.abbott.com
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Publication History

Publication Date:
31 December 2000 (online)

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A concise, stereocontrolled synthesis of N-protected (1S,1’S)-α-aminoepoxides, important intermediates for the preparation of hydroxyethylamine dipeptide isosteres, beginning with α-aminoesters is described.

α-aminoepoxide - hydroxyethylamine