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Synlett 1995; 1995(6): 609-611
DOI: 10.1055/s-1995-5041
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A Simple and Practical Deprotection of tert-Butyldimethylsilyl Ether and Allyl Ester in the Synthesis of 1-β-Methylcarbapenems

Masahiko Seki, Kazuhiko Kondo* , Tooru Kuroda, Takeshi Yamanaka, Tameo Iwasaki
  • *Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd., 16-89, Kashima-3-chome, Yodogawa-ku, Osaka 532, Japan
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Publication Date:
31 December 2000 (online)

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An efficient deprotection of t-butyldimethylsilyl ether and allyl ester of 1-β-methylcarbapenems by the use of inexpensive ammonium bifluoride and palladium acetate, respectively, is described.

1-β-methylcarbapenems - deallylation - desilylation