PDF herunterladen
Synlett 1995; 1995(7): 748-750
DOI: 10.1055/s-1995-5072
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Asymmetric Hydrogenation of Cyclic Ketimines Catalyzed by Iridium(I)-Complexes of BCPM and Its Analog1

T. Morimoto* , N. Nakajima1 , K. Achiwa1
  • *School of Pharmaceutical Sciences, University of Shizuoka, 51-1 Yada, Shizuoka-shi 422, Japan, Fax 54 264 5745
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

 als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

Modified pyrrolidinebisphosphines, BCPM (1a) and its analog MCCPM (1b), were found to be more efficient ligands than the original BPPM (2a) in the iridium(I)-catalyzed asymmetric hydrogenation of imines in the presence of iodide. In particular, the modified ligands (1a,b) showed very high enantioselectivity of up to 91% ee in the hydrogenation of 2,3,3-trimethylindolenine (6) in the presence of bismuth(III) iodide.

asymmetric hydrogenation - imine - pyrrolidinebisphosphine - iridium complex - catalyst