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Synlett 1995; 1995(8): 837-838
DOI: 10.1055/s-1995-5083
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Remarkable Kinetic Resolution of Chiral β-Keto Esters by Baker’s Yeast Reduction

Marcus Eh, Markus Kalesse*
  • *Institut für Organische Chemie, Universität Hannover, Schneiderberg 1b, D-30167 Hannover, Germany, Fax: +49-511 7624643, Email: Kalesse@mbox.oci.uni-hannover.de
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Publication History

Publication Date:
31 December 2000 (online)

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The reduction of chiral β-keto esters with baker’s yeast is described. Reduction of 10 yields highly functionalized diol 11 with excellent stereoselectivity and generates a useful intermediate for natural product syntheses.

Baker’s yeast reduction - β-keto esters - kinetic resolution - 1,3-diols