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Synlett 1995; 1995(10): 1075-1076
DOI: 10.1055/s-1995-5176
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Highly Enantioselective Route to β-Lactams via Intramolecular C-H Insertion Reactions of Diazoacetylazacycloalkanes Catalyzed by Chiral Dirhodium(II) Carboxamidates

Michael P. Doyle* , Alexey V. Kalinin
  • *Department of Chemistry, Trinity University, San Antonio, Texas 78212, U.S.A.
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Publication Date:
31 December 2000 (online)

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Exceptional enantiocontrol, up to 97% ee, has been achieved with the use of chiral dirhodium(II) carboxamidates in intramolecular C-H insertion reactions that produce β-lactams from diazoacetamides prepared from cyclic amines.

asymmetric catalysis - C-H insertion - diazoacetamides - β-lactams - chiral dirhodium(II) catalysts