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Synlett 1995; 1995(11): 1163-1164
DOI: 10.1055/s-1995-5210
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Applications of the Pummerer Rearrangement; Synthesis of a Functionalised Oxathiolane Intermediate to Anti-virals such as the Reverse Transcriptase Inhibitor 3TCTM

Owen Dwyer*
  • *Process Research Department, Glaxo Wellcome Research and Development Ltd., Gunnels Wood Rd, Stevenage SG1 2NY, UK, Tel. (01438) 763673, Fax (01438) 764869, Internet: POD14197@ggr.co.uk
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Publication History

Publication Date:
31 December 2000 (online)

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The Pummerer rearrangement was used to prepare a functionalised oxathiolane which can be converted to potent anti-virals such as the HIV Reverse Transcriptase Inhibitor 3TCTM.

Pummerer rearrangement - Oxothiolane - 3TCTM