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Synlett 1995; 1995(11): 1149-1150
DOI: 10.1055/s-1995-5212
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Synthesis of 3-Substituted Tetrahydroisoquinolines via Nucleophilic Addition to N-Tosyliminium Ions

Viviana L. Ponzo, Teodoro S. Kaufman*
  • *Instituto de Química Orgánica de Síntesis -IQUIOS- (CONICET-UNR) and Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 570, (2000) Rosario, Argentina
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Publication Date:
31 December 2000 (online)

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A new approach to the synthesis of 3-substituted tetrahydroisoquinolines by reaction of N-tosyliminium ions with silicon-based nucleophiles is reported. This strategy allowed an alternative elaboration of a simplified analog of MY336-a.

C-C bond formation - tetrahydroisoquinolines - N-tosyliminium ions - MY336-a analog