An Enantioselective Synthesis of the Antifungal Agent (2R, 3R)-2-(2,4-Difluorophenyl)-3-(methylsulfonyl)-1-(1,2,4-triazol-1-yl)-2-butanol (Sch 42427; SM 9164)

Frank Bennett; Ashit K. Ganguly; Viyyoor M. Girijavallabhan; Patrick A. Pinto

doi:10.1055/s-1995-5217

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Synlett 1995; 1995(11): 1110-1112
DOI: 10.1055/s-1995-5217

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An Enantioselective Synthesis of the Antifungal Agent (2R, 3R)-2-(2,4-Difluorophenyl)-3-(methylsulfonyl)-1-(1,2,4-triazol-1-yl)-2-butanol (Sch 42427; SM 9164)

Frank Bennett^* , Ashit K. Ganguly, Viyyoor M. Girijavallabhan¹ , Patrick A. Pinto

^*Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA

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Publication Date:
31 December 2000 (online)

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A synthesis of Sch 42427 (SM 9164) 1 ¹ is described utilising a novel two step olefin inversion process and a Sharpless asymmetric epoxidation (AE) reaction as the key steps.

antifungal - Sharpless epoxidation - olefin inversion