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Synlett 1995; 1995(12): 1219-1220
DOI: 10.1055/s-1995-5235
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Solid-Phase Synthesis of a 36 Amino Acid O-Fucosyl-peptide with the Uncommon Thr-Fuc Linkage

Hélène Hietter* , Michael Schultz, Horst Kunz
  • *Université Louis Pasteur, Laboratoire de chimie organique de substances naturelles, URA 31 CNRS, 5 rue Blaise Pascal, 67084 Strasburg, France
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Publication Date:
31 December 2000 (online)

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The solid-phase glycopeptide synthesis of a O-fucosylated 36 amino acid serine protease inhibitor from Locusta migratoria was carried out using Fmoc-Thr(α-Ac3Fuc)-OH as the key building block. The deprotected and purified glycopeptide was characterized by electrospray mass spectrometry and zone capillary electrophoresis.

Solid-phase synthesis - O-glycopeptide - fucosylated threonine - serine protease inhibitor