Download PDF
Synlett 1995; 1995(12): 1247-1248
DOI: 10.1055/s-1995-5257
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Stereocontrolled Functionalization at the C-9 of Retinal. Stereoselective Synthesis of 9-trans-9-Fluororetinal

Tetsuro Shinada, Noriko Sekiya, Nina Bojkova, Kazuo Yoshihara*
  • *Suntory Institute for Bioorganic Research, Wakayama-dai, Shimamoto-cho, Mishima-gun, Osaka 618, Japan, Fax 075-962-2115
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A general functionalization at the C-9 of retinal with 9-trans-selectivity is described. A palladium-catalyzed cross-coupling reaction of 6 and 7 afforded 6E-8, which was elaborated to 9-trans-9-fluororetinal via the stereo- and regioselective isomerization.

retinal - cross-coupling - Horner-Emmons reaction - conjugate addition - isomerization