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Synlett 1995; 1995(12): 1255-1256
DOI: 10.1055/s-1995-5258
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Asymmetric Synthesis of (S)-Chromanethanol as a Useful Synthetic Unit of Vitamin E Analogs

Eisaku Mizuguchi, Kazuo Achiwa*
  • *School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422, JAPAN
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Publication History

Publication Date:
31 December 2000 (online)

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The Optically active chromanethanol(1) was synthesized by utilizing the catalytic asymmetric Sharpless epoxidation as a key reaction. Cyclization of the diol(7) to the (S)-O-benzyl chromanethanol(8) with Ph3CBF4 in one step was observed to proceed with complete retention of the configuration.

chromanethanol - MDL-73404 - asymmetric epoxidation