Download PDF
Synlett 1995; 1995(12): 1243-1244
DOI: 10.1055/s-1995-5261
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Expeditious Synthesis of Enantiomerically Pure trans-4,5-Dihydroxy-2-cyclopenten-1-one

Koji Toyama, Satoru Iguchi, Tohru Oishi, Masahiro Hirama*
  • *Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-77, Japan
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A short-step synthesis of (-)-(4R,5S)- and (+)-(4S,5R)-trans-4,5-dihydroxy-2-cyclopenten-1-one derivatives (14) has been achieved via the enzymatic asymmetric transformations of meso-3,4,5-trans,trans-trihydroxycyclopentene derivatives 12 and 15, respectively.

4,5-trans-dihydroxy-2-cyclopenten-1-one - meso-compound - lipase - asymmetrization - neocarzinostatin chromophore