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Synlett 1995; 1995(SI): 475-490
DOI: 10.1055/s-1995-5299
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Chemical Explorations Driven by an Enchantment With Mitomycinoids - A Twenty Year Account

Samuel J. Danishefsky* , Jeffrey M. Schkeryantz
  • *Department of Chemistry, Columbia University, Havemeyer Hall, New York, N.Y. 10021; Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, N.Y. 10021
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Publication History

Publication Date:
31 December 2000 (online)

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The mitomycins and mitomycinoids have attracted considerable attention from chemists and biochemists ever since their discovery over twenty years ago. This account highlights the more important discoveries, as well as tribulations, that occurred in our group en route toward the synthesis of these important antitumor compounds.

mitomycinoid - mitomycin C - mitomycin K - FR-900482 - antibiotic - antitumor - leucomitomycin - aziridinomitosene