Synthesis 1996; 1996(4): 529-532
DOI: 10.1055/s-1996-4235
paper
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Synthesis of 3-(Alkylthio and Phenylthio)-1,1,1-trifluoroalkan-2-ones via Ring Opening of Epoxy Ethers

Jean-Pierre Bégué* , Danièle Bonnet-Delpon, Andrei Kornilov
  • *BioCIS-CNRS, Centre d’Etudes Pharmaceutiques, Rue J.B. Clément, F-92296 Châtenay-Malabry, France, Fax +33(1)46835740
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Regioselective ring opening of 1-trifluoromethyl epoxy ethers 2 was achieved with alkyl and phenyl sodium thiolates to afford new 3-(alkylthio and phenylthio)-1,1,1-trifluoroalkan-2-ones 3-5 in good yields.