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Synthesis 1996; 1996(4): 511-513
DOI: 10.1055/s-1996-4243
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Studies on Organophosphorus Compounds 92: A Facile Synthesis of 1-Substituted 5-Trifluoromethylimidazole-4-phosphonates

Weisheng Huang, Chengye Yuan*
  • *Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China, Fax +86(21)4166128; E-mail cisoc@rose.cnc.ac.cn
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Publication Date:
31 December 2000 (online)

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Base-induced cycloaddition of diethyl isocyanomethylphosphonate to trifluoroacetimidoyl chlorides gives 1-substituted diethyl 5-trifluoromethylimidazole-4-phosphonates with high regioselectivity.

based-induced cycloaddition - trifluoromethylimidazolephosphonates - high regioselective

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