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Synthesis 1996; 1996(6): 693-694
DOI: 10.1055/s-1996-4297
short paper
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A Short Synthesis of (Z)-15-Methylhexadec-11-enoic Acid

Elba D. Reyes, Néstor M. Carballeira*
  • *Department of Chemistry, University of Puerto Rico, P.O. Box 23346, San Juan, Puerto Rico 00931-3346, Fax +1(809)7510625; E-mail N-CARBALL@UPR1.UPR.CLU.EDU
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Publication Date:
31 December 2000 (online)

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The biologically intriguing (Z)-15-methylhexadex-11-enoic acid, a component of Myxococcus xanthus and Cyamopsis tetragonolobus, has been synthesized in 19% overall yield via the Wittig reaction of 4-methyl-1-pentyltriphenylphosphonium bromide and 10-bromodecanal. The title compound displayed marginal cytotoxicity against human cervix carcinoma (HeLa) and Chinese hamster ovary (CHO) cells.

fatty acids - Wittig reaction - 15-methylhexadec-11-enoic acid - cytotoxic