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Synthesis 1996; 1996(8): 997-1001
DOI: 10.1055/s-1996-4327
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Synthesis of 2-Substituted 6-Fluoroalkylpyrimidin-4(3H)-ones and -pyrimidines

Hui-Ping Guan, Qiao-Sheng Hu, Chang-Ming Hu*
  • *Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People’s Republic of China, Fax +86(21)64166128
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Publication Date:
31 December 2000 (online)

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Treatment of ethyl α-fluoroalkylacetates 1 or ethyl 3-fluoroalkyl-2-iodoacrylates 2 under mild conditions with amidine affords 2-substituted 6-fluoroalkylpyrimidin-4(3H)-ones 4, 5, 6, 7 in excellent yields, while α-fluoroalkyl alkyl ketones or α-fluoroalkyl aldehyde 3 give polysubstituted 6-fluoroalkylpyrimidines 8, 9 under the same conditions.

synthesis of fluoroalkylpyrimidones and -pyrimidines - fluoroalkylcarbonyl compounds - 3-fluoroalkyl-2-iodoacrylates - amidine