RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000084.xml
Synthesis 1996; 1996(8): 997-1001
DOI: 10.1055/s-1996-4327
DOI: 10.1055/s-1996-4327
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Synthesis of 2-Substituted 6-Fluoroalkylpyrimidin-4(3H)-ones and -pyrimidines
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
![](https://www.thieme-connect.de/media/synthesis/199608/lookinside/thumbnails/10.1055-s-1996-4327-1.jpg)
Treatment of ethyl α-fluoroalkylacetates 1 or ethyl 3-fluoroalkyl-2-iodoacrylates 2 under mild conditions with amidine affords 2-substituted 6-fluoroalkylpyrimidin-4(3H)-ones 4, 5, 6, 7 in excellent yields, while α-fluoroalkyl alkyl ketones or α-fluoroalkyl aldehyde 3 give polysubstituted 6-fluoroalkylpyrimidines 8, 9 under the same conditions.
synthesis of fluoroalkylpyrimidones and -pyrimidines - fluoroalkylcarbonyl compounds - 3-fluoroalkyl-2-iodoacrylates - amidine