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Synthesis 1996; 1996(8): 954-958
DOI: 10.1055/s-1996-4328
DOI: 10.1055/s-1996-4328
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Lipase-Mediated Resolution of trans-1-Azidoindan-2-ol: A New Route to Optically Pure cis-1-Aminoindan-2-ol
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Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
![](https://www.thieme-connect.de/media/synthesis/199608/lookinside/thumbnails/10.1055-s-1996-4328-1.jpg)
Optically pure trans-1-azidoindan-2-ol has been prepared in both enantiomeric forms via lipase-mediated kinetic transesterification in organic solvent. A route to optically pure cis-1-aminoindan-2-ol has also been developed by using the optically pure trans-azidoalcohol thus obtained.
lipase-mediated resolution - (1S,2S)- and (1R,2R)-trans-azidoindan-2-ol - (1S,2R)- and (1R,2S)-cis-aminoindan-2-ol - Mitsunobu inversion - HIV protease inhibitor - chiral auxiliary