PDF herunterladen
Synthesis 1996; 1996(11): 1305-1308
DOI: 10.1055/s-1996-4378
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Rapid Synthesis of an Advanced Functionalized Monocyclofarnesyl Intermediate Using 1,2-Dibromoethyl Ethyl Ether as a Bromoacetaldehyde Equivalent in the Synthesis of Furan-2(5H)-ones

F. W. Joachim Demnitz* , Ralph A. Raphael
  • *SANDOZ Pharma AG, Preclinical Research, 350 K06, Basel, CH-4002, Switzerland, Fax +41(61)3243036
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

The lithium enolate of the ℇ-lactone 10 was reacted with 1,2-dibromoethyl ethyl ether to furnish 12, treatment of which with aqueous K2CO3 gave a highly functionalized sesquiterpene of the monocyclofarnesyl skeleton the 3-substituted furan-2(5H)-one 13a.

butenolide synthesis - 1,2-dibromoethyl ethyl ether - furan-2(5H)-one synthesis - monocyclofarnesyl - sesquiterpene