PDF herunterladen
Synthesis 1996; 1996(11): 1363-1370
DOI: 10.1055/s-1996-4393
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Reaction of Active Methylene Compounds with α-Fluoroalkyl Ketones or Esters: A Convenient Synthesis of 4-Trifluoromethylpyridines and meta-Trifluoromethylphenols

Hui-Ping Guan, Chang-Ming Hu*
  • *Shanghai Institute of Organic Chemistry, Academia Sinica, 354 Fenglin Lu, Shanghai 200032, People’s Republic of China, Fax +86(21)64166128
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

 als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

The reaction of α-fluoroalkyl ketones 1 or ethyl α-fluoroalkylacetates 2 with active methylene compounds such as methyl acetoacetate (3), acetylacetone (4) and diethyl malonate (5) produced unsaturated fluoroalkyl-containing 1,5-dicarbonyl compounds 6, from which polyalkyl-substituted 4-trifluoromethylpyridines 7, 4-trifluoromethylpryrid-2(1H)-ones 8 and meta-trifluoromethylphenols 9 were synthesized conveniently.

A convenient synthesis of 4-trifluoromethylpyridines and meta-trifluoromethylphenols