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Synthesis 1996; 1996(4): 459-461
DOI: 10.1055/s-1996-4439
short paper
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Synthesis of 1,3-Dimethyl-8-(1,2,3,4-tetrahydroxybutyl)- and 1,3-Dimethyl-8-(1,2,3,4,5-pentahydroxypentyl)-7H-purine-2,6-(1H,3H)-diones

Alfonz Rybár* , Juraj Alföldi, Michal Fedoroňko, Ján Kozák
  • *Institute of Chemistry, Slovak Academy of Sciences, DK-84238 Bratislava,Slovak Republic, Fax +42(7)373811; E-mail chembabo@savba.savba.sk
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Publication Date:
31 December 2000 (online)

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An efficient method for the preparation of 8-(polyhydroxyalkyl)-7H-purine-2,6(1H,3H)-diones 5 starting from 6-chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (1) and 1-amino-1-deoxypentitols or -hexitols 2 via 1,3-dimethyl-6-(polyhydroxyalkylamino)-pyrimidine-2,4(1H,3H)-diones 3 and their 5-nitrosoderivatives 4 is described.

1,3-dimethyl-6-(polyhydroxyalkylamino)-pyrimidin-2,4(1H,3H)-diones - 1,3-dimethyl-5-nitroso-6-(polyhydroxyalkylamino)-pyrimidin-2,4(1H,3H)-diones - 1,3-dimethyl-8-(polyhydroxyalkyl)-1,3-dimethyl-7H-purin-2,6(1H,3H)-diones - cyclodehydration of 6-alkylamino-5-nitrosopyrimidines