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Synlett 1996; 1996(4): 324-326
DOI: 10.1055/s-1996-5429
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A Regio- and Stereocontrolled Synthesis of 13,14-Didehydroisocarbacyclin

Shun-ichi Hashimoto, Yoji Miyazaki, Shiro Ikegami*
  • *Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa 199-01, Japan
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Publication Date:
31 December 2000 (online)

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An expeditious synthesis of 13,14-didehydroisocarbacyclin via a convergent process has been accomplished, incorporating a novel method for the attachment of an alkynyl ω side chain unit to a bicyclo[3.3.0]octane skeleton.

α-alkynyl alcohol - alkynyllead(IV) triacetate - palladium-catalyzed deallyloxycarbonylation - cobalt carbonyl complex - prostacyclin analogue