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Synlett 1996; 1996(4): 371-372
DOI: 10.1055/s-1996-5432
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3,3-Difluoro-2-ethoxy-2-propenol: Preparation and Utility as a Novel Synthon of α,α-Difluoroketones

Guo-qiang Shi* , Wei-ling Cai
  • *Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, 200032 Shanghai, P.R. China
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Publication Date:
31 December 2000 (online)

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A novel preparation of 3,3-difluoro-2-ethoxy-2-propenol and its derivatives has been developed and their synthetic use as a synthon of α,α-difluoro ketones was demonstrated.

fluorinated synthon - α,α-difluoroketone - allylic alcohol