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Synlett 1996; 1996(5): 447-448
DOI: 10.1055/s-1996-5444
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A Direct Metalation Approach to 2-Alkylthio-2,2-Diaryl Substituted Acetic Acids

Fulvio Gualtieri, Alessandro Mordini* , Sabina Pecchi, Serena Scapecchi
  • *Centro CNR Composti Eterociclici, c/o Dipartimento di Chimica Organica ”U. Schiff”, via G. Capponi 9, I-50121 Firenze, Italy
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Publication History

Publication Date:
31 December 2000 (online)

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A series of 2-alkylthio-2,2-diaryl substituted acetic acids have been synthesized through a sequential metalation of diarylmethanes with the superbasic mixtures butyllithium/diisopropylamine/potassium tert-butoxide (LIDAKOR).

Metalation - muscarinic antagonist - superbase - alkyllithium - lithium amide - diarylsubstituted acetic acid