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Synlett 1996; 1996(5): 479-480
DOI: 10.1055/s-1996-5456
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Facile Lewis Acid-Mediated Ring Opening of 4-Hydroxypyrrolidin-2-ones by Amino Acid Esters

David P. Rotella*
  • *Department of Chemistry, Cephalon, Inc. 145 Brandwine Parkway, West Chester, PA 19380, FAX 610-344-0065, email drotella.cephalon@notes.ccmail.com
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Publication History

Publication Date:
31 December 2000 (online)

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Lewis acid mediated ring opening of 4-hydroxypyrrolidin-2-ones by certain amino acid t-butyl esters leads directly to hydroxyethylene dipeptides.

hydroxyethylene dipeptides - Lewis Acid - ring opening - amino acid esters