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Synlett 1996; 1996(5): 457-458
DOI: 10.1055/s-1996-5457
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Synthesis of Phosphotriester Cationic Phospholipids. Cationic Lipids 21

Igor Solodin, Carolyn S. Brown, Timothy D. Heath*
  • *School of Pharmacy, University of Wisconsin, 425 N. Charter St., Madison, WI 53706, USA
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Publication Date:
31 December 2000 (online)

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The synthesis of cationic phospholipids (CP) by neutralization of the negative charge of the phosphodiester moiety is described. It involves esterification of the remaining P-O- linkage of the phospholipid by reaction with substituted sulfochlorides in the presence of C1-C4 alcohols.

cationic lipids - phospholipids - cationic liposomes - gene transfection - drug delivery