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Synlett 1996; 1996(7): 665-666
DOI: 10.1055/s-1996-5545
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Facile Synthesis of Completely Protected Enantiomerically Pure α,α-Disubstituted α-Amino Acids

Bernhard Westermann* , Ina Gedrath
  • *Universität-GH Paderborn, Fachbereich für Chemie und Chemietechnik, Warburgerstr. 100, 33098 Paderborn, Germany, E-Mail: bw@chemie.uni-paderborn.de
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Publication History

Publication Date:
31 December 2000 (online)

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α,α-Disubstituted α-amino acids are synthesized from readily available β-ketoesters by a three step procedure: Beckmann rearrangement, protection of the lactam followed by nucleophilic ring opening.

amino acid - quaternary carbon centre - PLE-catalyzed saponification - peptide mimic